WASHINGTON, May 15 — Scientists reported yesterday more evidence that a certain antidepressant may cut the development of brain plaque implicated in Alzheimer's disease, this time by studying young people without dementia.
The antidepressant citalopram lowered by 37 per cent the amount of amyloid beta, the main ingredient in brain plaques, in a selection of 23 healthy adults aged 18-50.
The findings were published in the journal Science Translational Medicine.
Citalopram, a common selective serotonin reuptake inhibitor (SSRI) that was approved for the US market in 1998, also stopped the growth of existing brain plaques in mice with a model of Alzheimer's disease and cut new plaque growth 78 per cent.
Previous research has found some elderly people who have taken antidepressants also have less amyloid plaque than people who have not taken the mood-enhancing drugs.
Still researchers cautioned that they have not yet found evidence of a cause and effect.
“We are a long way from making a statement regarding the ability of SSRIs to prevent the cognitive decline associated with AD,” said lead author Yvette Sheline, professor of psychiatry, radiology and neurology at the University of Pennsylvania.
The patients in this study were followed for a 24 hour period. Future research will focus again on elderly people who take antidepressants, and follow them for a two-week period.
“If we see a drop in levels of amyloid beta in their spinal fluid after two weeks, then we will know that this beneficial reduction in amyloid beta is sustainable,” Sheline said. — AFP
