NEW YORK, Sept 18 — ABC just released the Grey’s Anatomy season 12 trailer, and it promises that ‘everything has changed’.

Ellen Pompeo, Sara Ramirez, Kevin McKidd, Justin Chambers, and more return for the new season, which will be the first without Patrick Dempsey, aka McDreamy, as his character was tragically killed off at the end of last season.

A screen grab showing a clip from the newly released trailer for Grey"s Anatomy Season 12.